https://yitenghsiaolab.github.io/research/ResearchHugo Blox Builder (https://hugoblox.com)en-usSun, 03 Aug 2025 00:00:00 +0000https://yitenghsiaolab.github.io/media/icon_hu8453028900461822433.pnghttps://yitenghsiaolab.github.io/research/https://yitenghsiaolab.github.io/research/r_01/Sun, 03 Aug 2025 00:00:00 +0000https://yitenghsiaolab.github.io/research/r_01/<p style="text-align: justify;"> We will develop a customizable interferometric scattering microscopy (iSCAT) platform with flexible illumination configurations, optimized for high-sensitivity imaging in dense and heterogeneous 3D cellular environments. This includes implementing adaptable optical geometries and coherence control to match the optical properties of different biological samples. </p>https://yitenghsiaolab.github.io/research/r_02/Sat, 02 Aug 2025 00:00:00 +0000https://yitenghsiaolab.github.io/research/r_02/<p style="text-align: justify;"> We will develop and validate temporal fluctuation analysis methods to extract molecule-specific physical quantities. This will involve integrating microrheology-based approaches and flow-field analysis to quantify viscoelastic properties, material density, diffusion mode, and dynamic flow characteristics at the nanoscale. </p>https://yitenghsiaolab.github.io/research/r_03/Fri, 01 Aug 2025 00:00:00 +0000https://yitenghsiaolab.github.io/research/r_03/<p style="text-align: justify;"> We will apply the developed platform to study biomphysics, in particular its dynamics, both in vitro and in living cells. </p>